Thermo Fisher Scientific CTDSP1 Monoclonal Antibody (OTI1B5), TrueMAB
CTDSP1 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI1B5). Western blot 및 IHC(P) 검증 완료. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도. 연구용 전용으로 안정적이며 고특이적 검출 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B5 |
| Immunogen | Full length human recombinant protein of human CTDSP1 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CTDSP1 is a class 2C phosphatase whose activity depends on the conserved DxD motif. Expression of CTDSP1 inhibits activated transcription from several promoter-reporter constructs, while a phosphatase-inactive mutant enhances transcription.
REST/NRSF complex recruits SCPs to neuronal genes containing RE1 elements, leading to neuronal gene silencing in non-neuronal cells. Phosphatase-inactive SCP forms interfere with REST/NRSF function and promote neuronal differentiation. SCP activity thus acts as a conserved transcriptional regulator that globally silences neuronal genes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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