Thermo Fisher Scientific CTDSP1 Monoclonal Antibody (OTI1B5), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CTDSP1 is a class 2C phosphatase whose activity depends on the conserved DxD motif. Expression of CTDSP1 inhibits activated transcription from several promoter-reporter constructs, while a phosphatase-inactive mutant enhances transcription.
REST/NRSF complex recruits SCPs to neuronal genes containing RE1 elements, leading to neuronal gene silencing in non-neuronal cells. Phosphatase-inactive SCP forms interfere with REST/NRSF function and promote neuronal differentiation. SCP activity thus acts as a conserved transcriptional regulator that globally silences neuronal genes.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.