Thermo Fisher Scientific CD3 Monoclonal Antibody (7D6), PE-Alexa Fluor 610

Applications

• Flow Cytometry (Flow): Assay-dependent
• View 3 publications

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• APC
• APC-Alexa Fluor 750
• FITC
• PE
• PE-Alexa Fluor 700
• PE-Cyanine5.5
• PE-Cyanine7
• PE-Texas Red
• TRI-COLOR
• Request custom conjugation

Product Specific Information

The R-phycoerythrin (PE)-Cy7 tandem conjugate permits simultaneous multicolor labeling and detection of multiple targets with excitation by a 488 nm laser without occupying traditional channels associated with FITC and PE.

Target Information

The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex.
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits (CD3 gamma, CD3 delta, CD3 epsilon, and CD3 zeta). These subunits are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.

CD3 components have long cytoplasmic tails that associate with signal transduction molecules, mediated by a double tyrosine-based motif. CD3 may play a role in TCR-induced growth arrest, cell survival, and proliferation.

The CD3 antigen is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum. It is not expressed on B or NK cells. Decreased T lymphocyte percentages may be observed in some autoimmune diseases.
Defects in the CD3 gene are associated with CD3 immunodeficiency.

Analyte Specific Reagent

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