Thermo Fisher Scientific CD3 Monoclonal Antibody (7D6), Alexa Fluor 488

Thermo Fisher Scientific CD3 Monoclonal Antibody (7D6), Alexa Fluor 488

Applications

• Flow Cytometry (Flow)

Tested Dilution: Assay-Dependent
Publications: View 1 publication

Product Specifications

Additional Formats

• Unconjugated
• APC
• APC-Alexa Fluor 750
• FITC
• PE
• PE-Alexa Fluor 610
• PE-Alexa Fluor 700
• PE-Cyanine5.5
• PE-Cyanine7
• PE-Texas Red
• TRI-COLOR
• Request custom conjugation

Product Specific Information

Based on testing and customer-reported results, Alexa Fluor™ 488 provides the best fluorescein (FITC) substitute for flow cytometry and other fluorescence-based assays.

Target Information

The CD3 subunit complex is crucial for transducing antigen-recognition signals into T cells and regulating the surface expression of the TCR complex. CD3 activation involves the cytoplasmic tails of CD3 gamma, delta, epsilon, and zeta subunits, which are structurally related members of the immunoglobulin superfamily encoded on human chromosome 11.

CD3 components have long cytoplasmic tails that associate with signal transduction molecules via double tyrosine-based motifs. CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation. The CD3 antigen is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells. Decreased T lymphocyte percentages may occur in some autoimmune diseases. Defects in CD3 genes are associated with CD3 immunodeficiency.

Classification

Analyte Specific Reagent

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