Thermo Fisher Scientific CD3 Monoclonal Antibody (7D6), APC-Alexa Fluor 750

Applications

• Flow Cytometry (Flow): Assay-dependent
  View 1 publication

• Miscellaneous PubMed (Misc): –
  View 2 publications

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 488
• APC
• FITC
• PE
• PE-Alexa Fluor 610
• PE-Alexa Fluor 700
• PE-Cyanine5.5
• PE-Cyanine7
• PE-Texas Red
• TRI-COLOR
• Request custom conjugation

Product Specific Information

The allophycocyanin (APC)-Alexa Fluor™ 750 dye tandem conjugate enables multicolor measurements using excitation by lasers emitting from 633 to 650 nm.

Target Information

The CD3 subunit complex is essential for transducing antigen-recognition signals into T cells and regulating surface expression of the TCR complex.
T cell activation involves CD3 gamma, delta, epsilon, and zeta subunits, which are structurally related members of the immunoglobulin superfamily encoded on human chromosome 11.
CD3 subunits have long cytoplasmic tails that associate with signal transduction molecules through tyrosine-based motifs.
CD3 is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells.
Decreased T lymphocytes may be observed in autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency.

Analyte Specific Reagent

제품 이미지