Thermo Fisher Scientific WWTR1 Monoclonal Antibody (CL0371)
WWTR1 단백질을 인식하는 Mouse monoclonal antibody(CL0371). Western blot, IHC, ICC/IF에 사용 가능. Hippo 신호전달 경로 연구 및 세포 증식 조절 연구에 적합. Protein A 정제, 액상 형태, 1 mg/mL 농도.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL0371 |
| Immunogen | Recombinant protein corresponding to Human WWTR1 (amino acids 36–175) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2637219 |
Product Specific Information
Immunogen sequence:
MNPKPSSWRK KILPESFFKE PDSGSHSRQS STDSSGGHPG PRLAGGAQHV RSHSSPASLQ LGTGAGAAGS PAQQHAHLRQ QSYDVTDELP LPPGWEMTFT ATGQRYFLNH IEKITTWQDP RKAMNQPLNH MNLHPAVSST
- Highest antigen sequence identity to orthologs: Mouse - 96%, Rat - 96%
- Binds to an epitope located within the peptide sequence SSWRKKILPESFFKE as determined by overlapping synthetic peptides.
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator acting as a downstream regulatory target in the Hippo signaling pathway. This pathway regulates organ size and tumor suppression by controlling cell proliferation and promoting apoptosis.
Key features include:
- Involvement in the kinase cascade with STK3/MST2, STK4/MST1, SAV1, and MOB1.
- Regulation of YAP1 and WWTR1/TAZ phosphorylation and inactivation.
- Enhances PAX8 and NKX2-1/TTF1-dependent gene activation.
- Regulates nuclear accumulation of SMADs and their coupling with transcriptional machinery.
- Plays a role in embryonic stem-cell self-renewal, cell proliferation, and epithelial-mesenchymal transition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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