Thermo Fisher Scientific Phospho-PYK2 (Tyr580) Polyclonal Antibody
인산화된 Tyr580 부위의 PYK2 단백질을 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 검증 완료. 인간, 마우스, 랫트 반응성. 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PTK2B (Accession Q14289), corresponding to amino acid residues around phosphorylated Tyr580. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818065 |
Product Specific Information
This antibody detects endogenous levels of PYK2 only when phosphorylated at Tyrosine 580.
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. It regulates actin cytoskeleton reorganization, cell polarization, migration, adhesion, and bone remodeling. FAK2 is essential for normal humoral immune response and B-cell migration. Aberrant expression is linked to various cancers, including gliomas, hepatocellular carcinoma, lung, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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