Thermo Fisher Scientific TAOK1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:5,000–1:20,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse

Target Information

TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs).
The activation of and binding to MEK3 by TAOK1 implicates it in the regulation of the p38-containing stress-responsive MAP kinase pathway.
TAOK1 (also known as MARKK) is a microtubule affinity-regulating kinase and an important regulator of mitotic progression, required for both chromosome congression and checkpoint-induced anaphase delay.
It participates in processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response, and regulation of cytoskeleton stability.
TAOK1 phosphorylates MAP2K3, MAP2K6, and MARK2, acting as an activator of the p38/MAPK cascade by mediating phosphorylation and activation of upstream kinases.
It is also involved in G-protein coupled receptor signaling to p38/MAPK14 and the G2/M transition DNA damage checkpoint.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.