Thermo Fisher Scientific TAOK1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:5,000–1:20,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse

Target Information

TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs).
It activates MEK3 and regulates the p38-containing MAP kinase pathway.
TAOK1 (also known as MARKK) is an important regulator of mitotic progression, required for chromosome congression and checkpoint-induced anaphase delay.
It participates in processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response, and cytoskeleton stability regulation.
TAOK1 phosphorylates MAP2K3, MAP2K6, and MARK2, and acts as an activator of the p38/MAPK cascade.
In response to DNA damage, TAOK1 contributes to G2/M transition checkpoint activation through phosphorylation of MAP2K3 and MAP2K6.
Additionally, it regulates cytoskeleton stability and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.