Thermo Fisher Scientific PRRT2 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Product Specifications

Product Specific Information

• Immunogen sequence:
  PKPALQPELP TQEDPTPEIL SESVGEKQEN GAVVPLQAGD GEEGPAPEPH SPPSKKSPPA NGAPPRVLQQ LVEEDRMRRA HSGHPGSPRG SLSRHPSSQL AGPGVEGGEG TQKPRDY

• Highest antigen sequence identity to orthologs:
  Mouse – 88%, Rat – 87%

Target Information

The proline-rich transmembrane protein 2 (PRRT2) contains a proline-rich domain in its N-terminal half and is predominantly expressed in brain and spinal cord during embryonic and postnatal stages. Mutations in PRRT2 are known to cause paroxysmal kinesigenic dyskinesia, characterized by brief attacks of abnormal involuntary movements triggered by sudden voluntary movements. PRRT2 may also be involved in benign familial infantile epilepsy (BFIE), an autosomal dominant epilepsy syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.