Thermo Fisher Scientific MMP12 Recombinant Rabbit Monoclonal Antibody (1C11)
MMP12 단백질을 표적하는 재조합 토끼 단클론 항체로 높은 특이성과 민감도를 제공. Western blot, IHC, IP 등에 적합하며 로트 간 일관성이 우수. 동물 유래 성분이 없는 포뮬레이션으로 연구용에 최적화.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunoprecipitation (IP) | 1:20 | View publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Hamster, Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1C11 |
| Immunogen | Synthetic peptide of human MMP12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2717289 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Matrix metalloproteinases (MMPs) are involved in extracellular matrix breakdown during normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in pathological conditions like arthritis and metastasis.
MMP12 specifically degrades soluble and insoluble elastin and may play a role in aneurysm formation and emphysema development. The gene is part of an MMP cluster localized to chromosome 11q22.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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