Thermo Fisher Scientific DCTN1 Polyclonal Antibody
Rabbit polyclonal antibody against human DCTN1 for WB and IHC applications. Recognizes Dynactin 1 protein region 120–170. Suitable for human, mouse, and rat samples. Lyophilized form, reconstituted in sterile water, stored at 4°C or -20°C.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 120–170 of human DCTN1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: DCTN1.
Target Information
The DCTN1 gene encodes the largest subunit of dynactin, a macromolecular complex of 10 subunits (22–150 kDa). Dynactin binds to microtubules and cytoplasmic dynein, participating in:
- ER-to-Golgi transport
- Lysosome and endosome movement
- Spindle formation and chromosome movement
- Nuclear positioning and axonogenesis
This subunit interacts with dynein intermediate chain and binds microtubules via a conserved CAP-Gly domain at its N-terminus. Alternative splicing produces multiple isoforms. Mutations cause distal hereditary motor neuronopathy type VIIB (HMN7B), also known as distal spinal and bulbar muscular atrophy (dSBMA).
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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