Thermo Fisher Scientific DCTN1 Polyclonal Antibody
DCTN1 단백질을 인식하는 sheep polyclonal antibody로 Western blot 및 IHC에 사용 가능. 인간, 마우스, 랫트 반응성. 합성 펩타이드(aa 120-170)로 면역화된 항원. PBS 버퍼, 무보존제, 동결건조 형태로 제공되며 연구용으로 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 10–50 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 10–50 µg/mL
Miscellaneous (PubMed)
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 120–170 of human DCTN1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: DCTN1.
Target Information
DCTN1 encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in various cellular functions such as ER-to-Golgi transport, lysosome and endosome movement, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.
This subunit interacts directly with dynein intermediate chain and binds to microtubules via a conserved CAP-Gly domain in its N-terminus.
Alternative splicing produces multiple isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B), also known as distal spinal and bulbar muscular atrophy (dSBMA).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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