Thermo Fisher Scientific RARB Polyclonal Antibody
Human 및 Mouse 시료에서 RARβ 단백질을 검출하는 Rabbit Polyclonal Antibody. Western blot, ICC/IF, ChIP, Gel Shift 등에 사용 가능. 비결합(Unconjugated) 상태로 제공되며 PBS buffer에 보관. -20°C에서 냉동 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 - 1:250 | - |
| ChIP assay (ChIP) | - | View 1 publication |
| Gel Shift (GS) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse, Yeast |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues P(429) S V S P S S V E N S G V S Q S P L L Q(448) of mouse RAR beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | PBS, whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2253602 |
Product Specific Information
PA1-811 detects retinoic acid receptor (RAR) beta from human and mouse tissues.
This antibody shows slight cross-reactivity to RAR alpha but does not detect RAR gamma.
PA1-811 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~52 kDa protein representing RAR beta from SH-SY5Y (human neuroblastoma) cell extract.
The PA1-811 immunogen is a synthetic peptide corresponding to residues P(429) S V S P S S V E N S G V S Q S P L L Q(448) of mouse RAR beta.
This immunizing peptide (Cat. # PEP-005) is available for use in neutralization and control experiments.
Target Information
Retinoic Acid (RA), an active metabolite of vitamin A, plays a key role in regulating the transition of proliferating precursor cells to postmitotic differentiated cells.
The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with RA receptors.
RAs may have therapeutic potential in cervical cancer and are known to play crucial roles in neuronal development.
Evidence suggests retinoid signaling regulates synaptic plasticity and learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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