Thermo Fisher Scientific TMP21 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Control: 293T, HepG2, Neuro2A, CD830, NIH-3T3, Raw264.7, C2C12, PC-12, Rat-2
• Predicted Reactivity: Zebrafish (95%), Rabbit (99%), Chicken (96%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is a component of the presenilin complex and modulates the γ-secretase but not the ε-secretase cleavage activity of the amyloid precursor protein. The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave amyloid precursor protein at γ- and ε-sites, leading to the accumulation of the Abeta product associated with Alzheimer’s disease. Co-immunoprecipitation experiments indicate TMP21 may regulate this complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory role.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.