Thermo Fisher Scientific Alpha A Crystallin Monoclonal Antibody (1H3.B8), PE
Alpha A Crystallin 단백질을 특이적으로 인식하는 Mouse Monoclonal Antibody (Clone 1H3.B8), PE 형광표지. Western blot, ICC/IF, ELISA에 사용 가능. 높은 특이성과 민감도 제공. 연구용으로만 사용.
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Thermo Fisher Scientific Alpha A Crystallin Monoclonal Antibody (1H3.B8), PE
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1H3.B8 |
| Immunogen | Native Alpha Crystallin |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931629 |
Additional Formats
- Unconjugated (MA5-27582)
- APC (MA5-45172)
- FITC (MA5-45173)
- PerCP (MA5-45174)
- Request custom conjugation (Custom Form)
Product Specific Information
0.5 µg/mL was sufficient for detection of 100 ng purified alphaA crystalline by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.
Detects approximately 20 kDa. Does not cross-react with alpha B-crystallin, beta L-crystallin, beta H-crystallin, gamma-crystallin, HSP25, HSP27, or HSP47 proteins.
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to maintain the proper refractive index.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest and composed of two primary gene products—alpha-A and alpha-B.
Alpha-crystallin functions as a molecular chaperone, preventing protein aggregation and possibly reducing cataract formation. Phosphorylated states of alpha-crystallin may occur in response to cellular stress, playing a role in protein maintenance.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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