Thermo Fisher Scientific p38 MAPK alpha Monoclonal Antibody (07)

Thermo Fisher Scientific p38 MAPK alpha Monoclonal Antibody (Clone 07)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody can be used in direct ELISA.

Target Information

MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs. The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other signals. p38 MAPK is inactive in the nonphosphorylated form and becomes activated by dual phosphorylation of a Thr-Gly-Tyr motif.
There are four isoforms of p38 MAPK differing in tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other stimuli, MAPK kinase-3 is phosphorylated and activates MAPK kinase-3/6, which in turn phosphorylate Thr180 and Tyr182 residues in p38 MAPK.
Phospho-p38 MAPK activates transcription factors such as ATF-2, CHOP-1, and MEF-2 through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.