Thermo Fisher Scientific p38 MAPK alpha Monoclonal Antibody (07)
Human p38 MAPK alpha 단백질을 인식하는 Mouse 모노클로날 항체. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용 가능. Protein A로 정제된 1 mg/mL 액상 형태로 제공. 연구용으로 세포 스트레스 및 염증 반응 연구에 적합.
- 카탈로그번호
- MA535978
- 판매단위
- pk
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Thermo Fisher Scientific p38 MAPK alpha Monoclonal Antibody (Clone 07)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:20–1:100 |
| ELISA | 1:1,000–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 07 |
| Immunogen | Recombinant Human p38 alpha / MAPK14 Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long-term storage, keep at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866590 |
Product Specific Information
This antibody can be used in direct ELISA.
Target Information
MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs. The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other signals. p38 MAPK is inactive in the nonphosphorylated form and becomes activated by dual phosphorylation of a Thr-Gly-Tyr motif.
There are four isoforms of p38 MAPK differing in tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other stimuli, MAPK kinase-3 is phosphorylated and activates MAPK kinase-3/6, which in turn phosphorylate Thr180 and Tyr182 residues in p38 MAPK.
Phospho-p38 MAPK activates transcription factors such as ATF-2, CHOP-1, and MEF-2 through phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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