Thermo Fisher Scientific CD115 (c-fms) Monoclonal Antibody (04)

Applications

• Flow Cytometry (Flow): 1:25–1:100

Product Specifications

Target Information

CSF1R (also known as FMS) is involved in the production, differentiation, and function of macrophages and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation.
CSF1R is a tyrosine kinase transmembrane receptor and a member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the CSF1R gene are associated with a predisposition to myeloid malignancy.
This receptor acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in regulating survival, proliferation, and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes such as macrophages and monocytes. It promotes the release of proinflammatory chemokines in response to IL34 and CSF1, contributing to innate immunity and inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.