Thermo Fisher Scientific TrkB Monoclonal Antibody (7H6E7B3)
인간 TrkB 단백질을 인식하는 마우스 단클론 항체로, Flow Cytometry 및 ELISA에 적합합니다. TrkA 및 TrkC와 교차 반응하지 않으며, 샌드위치 ELISA의 캡처 항체로 사용 가능합니다. 단백질 A 정제, PBS 용액 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1:25–1:100 |
| ELISA | 1:250–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7H6E7B3 |
| Immunogen | Recombinant Human Trk-B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866589 |
Product Specific Information
- No cross-reactivity in ELISA with Human Trk-A / NTRK1 / TRK, Human Trk-C / NTRK3 / TRKC, Mouse Trk-C / NTRK3 / TRKC.
- Can be used as a capture antibody in sandwich ELISA.
- Suitable for use in direct ELISA.
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system.
NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is involved in the development and maintenance of the nervous system and is a tyrosine kinase gene closely related to TrkA.
Expression is confined to tissues within the central and peripheral nervous systems.
BDNF and NT-3 can induce rapid phosphorylation on tyrosine of TrkB gp145, with BDNF being significantly more potent.
TrkB signaling leads to cell differentiation through the MAPK pathway.
Mutations in TrkB have been associated with obesity and mood disorders.
Alternate transcriptional splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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