Thermo Fisher Scientific CDK9 Polyclonal Antibody
CDK9 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 응용 분야(WB, IHC, ELISA, IP)에 사용 가능. 다른 CDK 계열 단백질과 교차 반응 없음. 세포 성장, 분화, 바이러스 병리 연구용에 적합. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000–1:50,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Multiple synthetic peptides corresponding to the C-terminal and N-terminal domains of human CDK9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1956780 |
Product Specific Information
This antibody does not cross-react with other cyclin-dependent kinases. Store as a concentrated solution. Centrifuge briefly prior to opening vial.
Target Information
CDK9 is a serine/threonine kinase that forms an active holoenzyme complex with CyclinT1, playing a key role in regulating the eukaryotic cell cycle.
It regulates cytokine-inducible transcription networks by facilitating promoter recognition of transcription factors and promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis.
The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro.
Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and predisposition to heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(PA1-29427_CDK9_P50750-1_Rabbit.svg 및 PA1-29427_CDK9_P50750-1_Rabbit_PDP.jpeg 이미지 참조)
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