Thermo Fisher Scientific MBD2 Polyclonal Antibody
MBD2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. Human 및 Mouse에 반응하며, HepG2와 mouse ES cell을 양성 대조로 권장합니다. Protein A로 정제된 액상 형태로 안정적 보관이 가능합니다.
- 카탈로그번호
- PA129386
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–2.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to human MBD2 (NP_056647) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2139741 |
Product Specific Information
- Recommended positive controls: HepG2, mouse ES cells
- Predicted reactivity: Cow 100%, Dog 100%, Guinea Pig 100%, Horse 100%, Mouse 100%, Rabbit 100%, Rat 100%, Zebrafish 93%
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. Mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules involved in gene silencing and chromatin structure. High-affinity recognition of methylated histone H3 by HP1 requires a functional chromodomain, which serves as a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-primary mouse fibroblasts but restored after reintroduction of catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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