Thermo Fisher Scientific TRPC4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

PA1-29441 is expected to react with human samples due to sequence homology.
Predicted molecular weight: 117 kDa.

Target Information

TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels.
TRPC4 forms a non-selective calcium-permeable cation channel activated by Gq-coupled receptors and tyrosine kinases.
It plays roles in endothelial permeability, vasodilation, neurotransmitter release, and cell proliferation.
Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for TRPC4.

The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel.
TRPC channels have seven TRPC genes (TRPC1–7) encoding channel proteins.
Diseases associated with TRPC4 include photosensitive epilepsy.

CaV3.3 encodes the pore-forming alpha subunit of a voltage-gated calcium channel, a low voltage-activated T-type calcium channel.
CaV3.3 channels show slower activation/inactivation compared to other T-type channels and may be involved in neuronal calcium signaling.
Alternate splicing results in multiple transcript variants.
Voltage-gated calcium channels (CaV) mediate calcium influx in response to depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression.
Diseases associated with CACNA1I include childhood absence epilepsy.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.