Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (IP26), Biotin, eBioscience

Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (IP26), Biotin, eBioscience™

Applications

• Flow Cytometry (Flow)

Tested Dilution: 0.5 µg/test
Publications: View 2 publications

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 700
• APC
• APC-eFluor 780
• eFluor 450
• FITC
• NovaFluor Blue 510
• NovaFluor Blue 610-70S
• NovaFluor Red 710
• NovaFluor Yellow 590
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• PE
• PE-Cyanine5
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 600
• Super Bright 780
• Request custom conjugation

Product Specific Information

Description:
The IP26 monoclonal antibody reacts with the alpha/beta chain of human TCR. The alpha/beta TCR is expressed by the majority of peripheral T cells.

Applications Reported:
The IP26 antibody has been reported for use in flow cytometric analysis.

Applications Tested:
The IP26 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. It can be used at ≤ 0.5 µg per test.
A test is defined as the amount of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically (10⁵–10⁸ cells/test).
It is recommended to titrate the antibody for optimal performance.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer non-covalently associated with invariant CD3 subunits (gamma, delta, eta, zeta). These are required for efficient surface expression.
T cell activation through the TCR induces differentiation, proliferation, and cytokine production.
Most peripheral T cells express TCR alpha/beta heterodimers, while gamma/delta T cells are mainly found in epithelial tissues and infection sites.
Proper assembly of TCR-CD3 complex in the endoplasmic reticulum is essential for surface expression.
TCR recognition of self-peptides relates to autoimmune diseases and tumor-associated mutations.
Superantigen engagement of TCRs can lead to toxic shock syndrome.
Autoantibodies to V beta segments have been isolated from RA and SLE patients, potentially modulating immune responses.
Gamma-delta T cells exhibit antitumor and immunoregulatory activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.