Thermo Fisher Scientific CD53 Recombinant Rabbit Monoclonal Antibody (104)
Cynomolgus CD53 특이성을 가진 Thermo Fisher의 재조합 토끼 단클론 항체. WB, ELISA, IP에 적합하며 높은 특이성과 재현성을 제공. 보존제가 없는 액상 형태로 제공되며 장기 보관 시 -20°C 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1:5,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 1–4 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cynomolgus monkey |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 104 |
| Immunogen | Recombinant Cynomolgus CD53 Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2784923 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to prevent contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal production candidates.
Advantages:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal-origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody specifically recognizes Cynomolgus CD53.
Target Information
CD53 is a tetraspanin family transmembrane glycoprotein expressed in lymphoid-myeloid lineages. It forms complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4, and tetraspanins CD37, CD81, CD82, modulating signaling processes.
CD53 contributes to tumor cell radioresistance and exhibits anti-apoptotic effects. In thymus, CD53 is upregulated during T cell positive selection and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, while neutrophil stimulation leads to downregulation of CD53 expression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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