Thermo Fisher Scientific Human FGF4 Synthetic Peptide
인간 FGF4의 카르복시 말단 18개 아미노산 서열에 해당하는 합성 펩타이드로, PA5-20483 항체의 블로킹 실험에 사용 가능. 정제된 액상 형태이며 PBS(pH 7.2, 0.1% BSA) 버퍼에 보관. 연구용으로만 사용.
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Thermo Fisher Scientific Human FGF4 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the carboxy terminus of human FGF4.
PEP-0603 can be used as a blocking peptide with polyclonal antibody PA5-20483.
Target Information
Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possesses broad mitogenic and cell survival activities. It plays key roles in the growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis.
FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and in adult mouse testis, intestine, and brain.
Studies on the mouse homolog suggest a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation.
Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at later stages of development.
Usage Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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