Thermo Fisher Scientific Human ATG16L1 Synthetic Peptide
인간 ATG16L1 단백질의 N-말단 18 아미노산 서열을 기반으로 한 합성 펩타이드. ATG16L1 항체의 차단용 블로킹 펩타이드로 사용 가능. 자가포식 관련 연구에 활용. PBS 기반 완충액에 0.1% BSA 함유, -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the amino terminus of human ATG16.
PEP-0602 can be used as a blocking peptide with polyclonal antibody PA5-20482.
Target Information
Autophagy related protein 16 L is encoded by the ATG16L gene and is located on chromosome 2 in humans. It is also known as WD30 or IBD10 (Inflammatory Bowel Disease 10).
ATG12 and ATG5 conjugate with each other and undergo homo-oligomerization with ATG16L to form an 800 kDa complex called the Atg16L complex.
This complex facilitates coupling or lipidation of LC3 to phosphatidylethanolamine (PE), a widely used marker for autophagy.
The ATG16L complex, along with other ATGs such as ATG18 and ATG21, prevents premature cleavage of ATG8-PE by the cysteine protease Atg4 until autophagosome completion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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