Thermo Fisher Scientific Human FBXL20 Synthetic Peptide

Thermo Fisher Scientific Human FBXL20 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the carboxy terminus of human SCRAPPER.
PEP-0605 can be used as a blocking peptide with polyclonal antibody PA5-20485.

Target Information

Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif.
SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases.
Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS, and is abundant at presynaptic membrane.
Scrapper has orthologs in C. elegans, D. melanogaster, and mammals, suggesting it functions as an important membrane-localized E3 ligase in various species.
Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to regulate synaptic transmission.
This identifies protein degradation as a mechanism for maintaining synaptic communication balance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.