Thermo Fisher Scientific Human FBXL20 Synthetic Peptide
인간 FBXL20 유래 합성 펩타이드로 항체 차단 실험 등에 활용 가능. 18개의 아미노산 서열로 구성되어 있으며, 액상 형태로 제공. 정제된 PBS 버퍼에 0.1% BSA와 0.02% sodium azide 포함. 연구용으로만 사용 가능.
- 카탈로그번호
- PEP0605
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human FBXL20 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the carboxy terminus of human SCRAPPER.
PEP-0605 can be used as a blocking peptide with polyclonal antibody PA5-20485.
Target Information
Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif.
SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases.
Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS, and is abundant at presynaptic membrane.
Scrapper has orthologs in C. elegans, D. melanogaster, and mammals, suggesting it functions as an important membrane-localized E3 ligase in various species.
Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to regulate synaptic transmission.
This identifies protein degradation as a mechanism for maintaining synaptic communication balance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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