Thermo Fisher Scientific Human FBXL20 Synthetic Peptide
Human FBXL20 단백질의 N-말단 18개 아미노산 서열에 해당하는 합성 펩타이드로, PA5-20486 항체의 블로킹용으로 사용 가능. 정제된 액상 형태, 200 µg/mL 농도, PBS(pH 7.2) + 0.1% BSA 저장. 연구용으로만 사용.
- 카탈로그번호
- PEP0606
- 판매단위
- pk
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Thermo Fisher Scientific Human FBXL20 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the amino terminus of human SCRAPPER.
PEP-0606 can be used as a blocking peptide with polyclonal antibody PA5-20486.
Target Information
Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases.
Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS, and is abundant at presynaptic membrane.
Scrapper has orthologs in C. elegans, D. melanogaster, and mammals, suggesting that it functions as an important membrane-localized E3 ligase in various species.
Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission.
This identifies protein degradation as a mechanism for holding synaptic communication in check.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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