Thermo Fisher Scientific Phospho-PSD-95 (Ser142) Polyclonal Antibody
PSD-95 단백질의 Ser142 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Human, Mouse, Rat 시료에 반응하며 Western blot에 적합. 고순도 액상 형태로 제공되며, -20°C에서 안정적으로 보관 가능.
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Thermo Fisher Scientific Phospho-PSD-95 (Ser142) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DLG4 (Accession P78352), corresponding to amino acid residues around phosphorylated Ser142 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817035 |
Product Specific Information
Antibody detects endogenous levels of PSD-95 only when phosphorylated at Ser142.
Target Information
Post Synaptic Density 95 kDa (PSD-95), also known as synapse-associated protein 90 kDa (SAP90), is a membrane-associated protein found in the postsynaptic density of forebrain neurons and in certain presynaptic structures of the cerebellum.
PSD-95 contains three PDZ domains, followed by an SH3 domain and a guanylate kinase homology (GuK) domain. It is involved in clustering of proteins such as NMDA receptors and Shaker-type potassium channels at the synaptic membrane in CNS neurons.
PSD-95 interacts with other proteins via two main modes: through PDZ domain binding to C-terminal T/SXV motifs and via PDZ–PDZ interactions, such as with neuronal nitric oxide synthase (nNOS).
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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