Thermo Fisher Scientific Phospho-PDE11A (Ser162) Polyclonal Antibody, FITC
Thermo Fisher의 Phospho-PDE11A (Ser162) FITC 결합 폴리클로날 항체로, Western blot, ELISA, IP에 적합합니다. 토끼 유래 IgG로 제작되었으며, 형광 검출(Ex/Em 498/517 nm)에 최적화되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 100–150 on PDE11A protein, phosphorylated at Ser117 & Ser124 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, containing 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20 °C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The 3’,5’-cyclic nucleotides cAMP and cGMP act as second messengers in various signal transduction pathways. 3’,5’-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to their corresponding 5’-monophosphates, providing a mechanism to downregulate cAMP and cGMP signaling.
The PDE11A gene encodes a member of the PDE protein superfamily. Mutations in this gene are associated with Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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