Thermo Fisher Scientific Phospho-PDE11A (Ser163) Polyclonal Antibody
Phospho-PDE11A (Ser163) 폴리클로날 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, ELISA, IP에 사용 가능하며, 합성 인산화 펩타이드를 면역원으로 제작되었습니다. 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 100–200 on rat PDE11A protein (Phosphorylated Ser163) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The 3’,5’-cyclic nucleotides cAMP and cGMP act as second messengers in various signal transduction pathways. 3’,5’-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to their corresponding 5’-monophosphates, providing a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are associated with Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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