Thermo Fisher Scientific IL3RA/CD123 Monoclonal Antibody (IL3RA, 1531)
인간 IL3RA/CD123 단백질을 인식하는 Mouse monoclonal antibody. IHC(P) 및 Peptide Array에 사용 가능. Recombinant fragment(aa 26-171)로부터 제작. Protein A/G 정제, PBS buffer, 무보존제. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL3RA, 1531 |
| Immunogen | Recombinant fragment of human IL3RA protein (around aa 26–171) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
IL-3Ra (Interleukin-3 receptor subunit alpha) belongs to the type I cytokine receptor family and forms a heterodimer with a unique alpha chain paired with the common beta (βc or CDw131) subunit.
It mediates the signal transmission of Interleukin-3. IL-3Ra and IL-3Rb heterodimerization is induced by Interleukin-3, which is necessary for receptor activation but not for high-affinity binding.
IL-3Ra subunits are reported to be overexpressed on acute myeloid leukemia (AML) blasts compared to normal hematopoietic cells, making them potential targets for novel therapeutic agents.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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