Thermo Fisher Scientific Interleukin-3 (IL-3) Monoclonal Antibody (IL3/4005)
인간 IL-3를 인식하는 마우스 단클론 항체로, IHC, Peptide Array, Immunoelectrophoresis 등에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, 4°C에서 보관. 인간 IL-3 관련 세포 성장 및 분화 연구에 적합.
- 카탈로그번호
- 3562-MSM5-P1
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL3/4005 |
| Immunogen | Recombinant fragment of human IL3 protein (amino acids 20–152) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human thymus or tonsil tissue
- Cellular Localization: Secreted
Specificity Comments:
Interleukin-3 (IL-3) is a pleiotropic cytokine primarily secreted by activated T lymphocytes. It stimulates proliferation and differentiation of hematopoietic cells, supporting growth of both pluripotent stem cells and committed progenitors. IL-3 also protects mast cells from apoptosis and activates the MAP kinase signaling pathway via JAK2-mediated phosphorylation and subsequent Stat5a/b activation.
Target Information
Interleukin 3 (IL-3), also known as Mast Cell Growth Factor (MCGF), Multi-Colony Stimulating Factor (multi-CSF), or Eosinophil-CSF (E-CSF), is produced by activated T cells, mast cells, and eosinophils.
IL-3 acts as a hematopoietic growth factor stimulating colony formation of erythroid, megakaryocyte, neutrophil, eosinophil, basophil, mast cell, and monocytic lineages.
Its activity is species-specific — human IL-3 does not act on mouse cells. IL-3 supports proliferation, differentiation, and apoptosis regulation in hematopoietic cells and may also have neurotrophic functions linked to neurological disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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