Thermo Fisher Scientific EBP50 Polyclonal Antibody
Rabbit polyclonal antibody targeting human EBP50 (NHERF1), validated for WB, IHC, and ICC/IF. Unconjugated, antigen affinity purified, and supplied as liquid form. Designed for research use with reliable specificity and performance.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50 | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide surrounding Ala310 of human NHERF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 10 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11009365 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
NHERF1 (Na⁺/H⁺ exchanger regulatory factor 1), also known as EBP50 (ezrin, radixin, moesin-binding phosphoprotein 50), is an adaptor protein that associates with beta-catenin and is required for its localization at cell-cell junctions. It interacts with various G protein-coupled receptors and regulates their trafficking, sodium-hydrogen exchange, and sodium-dependent phosphate transport. NHERF1/EBP50 inhibits cell motility and is essential for suppressing anchorage-independent growth. It contains a C-terminal ERM-binding region and two N-terminal PDZ domains, enabling head-to-tail intramolecular conformation to regulate its interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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