Thermo Fisher Scientific CD4 Chimeric Recombinant Rabbit Monoclonal Antibody (MT310)
CD4 항원 인식용 재조합 토끼 단클론 항체로 HIV-1 gp120 결합 부위에 특이적으로 결합합니다. IHC, Flow Cytometry, IP 등 다양한 응용에 적합하며, 인간 및 원숭이 종에 반응합니다. 고순도 Protein A 정제, 액상 형태로 안정적 보관 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/mL
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cynomolgus monkey, Human, Rhesus monkey |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MT310 |
| Immunogen | Proprietary sequence |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074289 |
Product Specific Information
Specificity: MT310 binds to the extracellular domain D1 of CD4—the same site as the HIV-1 gp120-binding site.
Target Information
The CD4 antigen is involved in the recognition of MHC class II molecules and acts as a co-receptor for HIV. CD4 is primarily expressed in T helper cells but may also be found in monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression occurs in thymus, lymph nodes, tonsils, spleen, and specific regions of the brain and gut. CD4 facilitates early T-cell activation through association with the T-cell receptor complex and Lck kinase, and may play a role in neuronal damage in infectious or immune-mediated CNS diseases. Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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