Thermo Fisher Scientific CD19 Recombinant Mouse Monoclonal Antibody (4G7)
인간 CD19 항원을 인식하는 마우스 유래 재조합 단클론 항체로, ICC/IF 및 유세포분석에 적합합니다. HEK293 세포에서 발현되었으며 Protein A로 정제된 액상형 제품입니다. 연구용으로만 사용되며 B세포 관련 연구에 유용합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4G7 |
| Immunogen | Human CCL (chronic lymphocytic leukemia) cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074290 |
Product Specific Information
Specificity: Recognises human CD19.
Target Information
CD19 is a member of the immunoglobulin superfamily and has two Ig-like domains. The CD19 molecule is expressed on 100% of peripheral B cells as defined by expression of kappa or lambda light chains.
It also appears on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have shown that CD19 is the earliest and broadest B cell-restricted antigen.
CD19 acts as a functional regulator of normal and malignant B cell proliferation and is expressed in all B cell precursor leukemias.
It serves as a signal-amplifying coreceptor for the B cell receptor (BCR) and can also signal independently of BCR co-ligation.
Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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