Thermo Fisher Scientific MUC1 Chimeric Recombinant Rabbit Monoclonal Antibody (SM3)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Specificity: Recognises the under-glycosylated form of human MUC1, a marker of tumours.

Target Information

MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, and EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages.
It is a transmembrane glycoprotein with a large mucin-like extracellular domain that matures through several intermediate forms generated by proteolysis and sequential addition and processing of numerous O-linked glycans that are heavily sialylated.

MUC1 is highly polymorphic, with each allele encoding a product containing a different number of repeats (between 30 and 90), leading to large differences in molecular weight. It is abundantly expressed in over 90% of breast carcinomas and metastases.

Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several alternatively spliced variants. Overexpression, aberrant intracellular localization, and changes in glycosylation of MUC1 have been associated with carcinomas.

Multiple alternatively spliced transcript variants encoding different isoforms of MUC1 have been reported, though the full-length nature of only some has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.