Thermo Fisher Scientific Androgen Receptor Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%), Pig (100%), Rabbit (100%), Sheep (100%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%).
• Positive Control: LNCaP.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain.

The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes.

The AR signaling pathway plays a key role in the development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain.

Androgen Receptor is a phosphoprotein that regulates mitogen-activated protein kinase (MAP kinase). Inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.