Thermo Fisher Scientific CTNNA3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
VSAFQRTFES LKNVANKSDL QKTYQKLGKE LENLDYLAFK RQQDLKSPNQ RDEIAGARAS LKENSPLLHS ICS

Sequence identity:

• Mouse: 92%
• Rat: 38%

Target Information

Catenins are proteins that connect cadherin/beta-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alphaT-catenin is expressed in other tissues, with the highest levels observed in the heart. Immunohistochemical analysis showed human alphaT-catenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of the testis.
It has been demonstrated that alphaT-catenin can functionally restore cell-cell adhesion in colon cancer cells lacking alpha-catenins, indicating its involvement in the formation of specific cell-cell contacts in muscle cells. The encoded protein has a predicted size of approximately 100 kDa and shares 57% amino acid identity with other alpha-catenins. In cells transfected with alphaT-catenin cDNA, interaction with alpha-catenin was confirmed by co-immunoprecipitation. The 892_24D2S antibody against alphaT-catenin does not cross-react with alphaE-catenin or alphaN-catenin in western blot analysis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.