Thermo Fisher Scientific Ubiquilin 4 Polyclonal Antibody
Human Ubiquilin 4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼(40% glycerol, 0.02% sodium azide) 내 액상 형태로 제공됩니다. 연구용 전용 제품입니다.
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- PA563986
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- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Ubiquilin 4. Recombinant protein control fragment (Product # RP-104299) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2649197 |
Product Specific Information
Immunogen sequence:
EGTGGSGTSQ VHPTVSNPFG INAASLGSGM FNSPEMQALL QQISEN
Highest antigen sequence identity:
- Mouse: 100%
- Rat: 100%
Target Information
The ubiquitin-proteosome pathway of protein degradation ensures proper cellular protein levels. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain-containing protein family participates in proteosomal degradation.
CIP75 (also known as ubiquilin-4) interacts with proteins such as Ataxin-1 and Connexin-43, increasing their turnover rate. Overexpression of CIP75 reduces Connexin-43 half-life, while siRNA knockdown has the opposite effect.
CIP75 contains:
- N-terminal UbL domain interacting with the 26S proteosome complex
- C-terminal UBA domain mediating interaction with Connexin-75
At least three isoforms of CIP75 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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