Thermo Fisher Scientific CD4 Chimeric Recombinant Rabbit Monoclonal Antibody (EDU-2 (B486))
CD4 단백질을 인식하는 토끼 재조합 단클론 항체로, IHC, ICC/IF, 유세포분석 등 다양한 면역분석에 사용 가능. 인간 시료 반응성, Protein A 정제, 액상 형태로 제공. HIV 수용체 연구 및 T세포 활성화 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | EDU-2 (B486) |
| Immunogen | This antibody was raised by immunizing mice with stimulated human leukocytes. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074724 |
Product Specific Information
Specificity: EDU-2 (B486) recognizes CD4, a membrane glycoprotein of T lymphocytes that interacts with MHC class II antigens and serves as a receptor for human immunodeficiency virus (HIV).
Target Information
The CD4 antigen is involved in the recognition of MHC class II molecules and acts as a co-receptor for HIV. CD4 is mainly expressed on T helper cells, but also on monocytes, macrophages, and dendritic cells. Tissue-level expression includes thymus, lymph nodes, tonsils, spleen, and certain regions of the brain and gut. CD4 plays a role in initiating or enhancing T-cell activation via the T-cell receptor complex and protein tyrosine kinase Lck. It may also mediate neuronal damage in infectious and immune-mediated CNS diseases. Multiple alternatively spliced transcripts have been identified (RefSeq, July 2017).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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