Thermo Fisher Scientific CD73 Chimeric Recombinant Rabbit Monoclonal Antibody (AD2)

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Assay-dependent

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:1,000

Flow Cytometry (Flow)

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

This antibody is specific for human CD73, a 70 kDa GPI-linked 5'-nucleotidase. It does not show cross-reactivity with mouse CD73.

Target Information

CD73 (Ecto-5'-nucleotidase, 5'-ribonucleotide phosphohydrolase) catalyzes the conversion of purine 5'-mononucleotides to nucleosides at neutral pH, primarily AMP.
It forms a dimer of two identical 70 kDa subunits bound to the plasma membrane via a glycosyl phosphatidylinositol (GPI) linkage.
CD73 serves as a marker for lymphocyte differentiation, and its deficiency is associated with various immunodeficiency disorders.

Other forms of 5'-nucleotidase exist in the cytoplasm and lysosomes and differ in substrate affinity, magnesium ion requirement, ATP activation, and phosphate inhibition.
The CD73 gene is localized to chromosome 6q14-q21. Mutations can lead to joint and arterial calcification and intestinal tuberculosis.
Two transcript variants encoding different isoforms of CD73 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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