Thermo Fisher Scientific CHRM2 Recombinant Rabbit Monoclonal Antibody (ARC1225)
CHRM2 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ELISA 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며 고순도의 HEK293 발현 시스템에서 생산되었습니다. 안정한 PBS/glycerol 저장 용액 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1225 |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human Muscarinic AChR M2 (ACM2) (P08172) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.55 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849562 |
Product Specific Information
Immunogen sequence:
LALDYVVSNA SVMNLLIISF DRYFCVTKPL TYPVKRTTKM AGMMIAAAWV LSFILWAPAI LFWQFIVGVR TVEDGECYIQ FFSNAAVTFG TAIAAFYLPV I
Target Information
Muscarinic cholinergic receptor 2 (CHRM2) is an acetylcholine receptor suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor also mediates smooth muscle contractility. In Alzheimer’s disease, selective loss of M2 subtype receptors occurs in cortical and hippocampal regions. Increased M2 receptor heterozygosity has been associated with depression in women. The M2 receptor is expressed in various brain regions including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, as well as in lung and prostate tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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