Thermo Fisher Scientific KCNIP3 Polyclonal Antibody
Thermo Fisher Scientific의 KCNIP3 Polyclonal Antibody는 마우스 및 랫트 시료에서 사용 가능한 Rabbit Ig 폴리클로날 항체입니다. Western blot 및 IHC에 적합하며, Calsenilin에 특이적으로 반응합니다. 연구용으로만 사용되며 장기 보관 시 -20°C 권장됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from N-terminal region of mouse KCNIP3 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Calsenilin
Target Information
Voltage-gated potassium (Kv) channels are key components of potassium currents in the heart and central nervous system. Kv4 channels are involved in the repolarization phase of cardiac action potentials and help prevent reverse-propagation in the brain.
KChIPs (Kv channel interacting proteins) are calcium-binding proteins that associate with Kv4 alpha-subunits to modulate their function.
Known KChIPs include:
- KChIP1: expressed in brain
- KChIP2: expressed in brain, heart, and lung (isoforms a, b, c)
- KChIP3 (Calsenilin/DREAM): expressed in brain and testis
KChIP3 not only modulates Kv4 currents but also binds to DRE regulatory elements to repress transcription of early-response genes such as c-fos. It is the first known calcium-binding protein functioning as a DNA-binding transcriptional regulator. KChIP3 is also associated with presenilins and implicated in β-amyloid formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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