Thermo Fisher Scientific KCNIP3 Polyclonal Antibody
KCNIP3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 IHC에 사용 가능. 인간 시료 반응성. Calsenilin 특이성. 연구용으로만 사용.
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human KCNIP3 conjugated to blue carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Calsenilin.
Target Information
Voltage-gated potassium (Kv) channels are essential components of potassium currents in the heart and central nervous system.
In the heart, Kv4 channels participate in the repolarization phase of the action potential, while in the brain they prevent reverse-propagation of action potentials.
Kv4 channels are associated with calcium-binding proteins known as KChIPs (Kv channel interacting proteins), which modulate channel function.
There are three known KChIPs:
- KChIP1: Expressed in the brain
- KChIP2: Expressed in brain, heart, and lung (three isoforms: a, b, c)
- KChIP3: Also known as calsenilin or DREAM (DRE-antagonist modulator), expressed in brain and testis
KChIP3 not only modulates Kv4 currents but also binds to regulatory DRE elements and represses transcription of the early-response gene c-fos, functioning as a calcium-binding transcriptional regulator.
It is also associated with presenilins and implicated in beta-amyloid formation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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