Thermo Fisher Scientific CD8 Monoclonal Antibody (fCD8), Biotin
고양이 CD8 항원을 인식하는 mouse IgG1 단클론 항체로, Biotin으로 표지되어 있습니다. Flow Cytometry에 적합하며, 1 µg/10^6 cells 농도로 사용됩니다. PBS(pH 7.4) 용액에 보관하며 4°C에서 안정적입니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA528791
- 판매단위
- pk
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | fCD8 |
| Immunogen | Feline thymocytes |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.4 |
| Contains | <0.1% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745750 |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family. It plays a key role in signal transduction, T cell differentiation, and activation.
CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α and CD8β) and functions as a co-receptor with TCR for MHC-I molecules.
CD8α is essential for MHC-I binding and is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers.
Upon MHC-I/peptide complex binding, CD8 recruits Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs are critical for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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