Thermo Fisher Scientific CD8 Monoclonal Antibody (fCD8)
고양이 CD8 항원을 인식하는 Mouse IgG1 단클론 항체로, Flow Cytometry에 적합합니다. 비결합형 액상 형태이며 0.5 mg/mL 농도로 제공됩니다. 4°C에서 보관하며 방부제가 포함되지 않습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA528794
- 판매단위
- pk
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Thermo Fisher Scientific CD8 Monoclonal Antibody (fCD8)
Applications
- Flow Cytometry (Flow): Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | fCD8 |
| Immunogen | Feline thymocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745753 |
Additional Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a critical role in signal transduction, T cell differentiation, and activation.
CD8 is primarily expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β) and functions as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
Additionally, CD8α can form homodimers found on subsets of T cells, NK cells, monocytes, and dendritic cells.
Upon MHC-I/peptide complex binding, CD8 recruits Lck kinase, leading to cytokine production, motility, and activation of cytotoxic T lymphocytes (CTLs).
Activated CTLs are essential for pathogen and tumor cell clearance. Differentiation of naïve CD8+ T cells into CTLs is promoted by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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