Thermo Fisher Scientific NeuN Recombinant Rabbit Monoclonal Antibody (14H6L24)
NeuN 단백질을 인식하는 재조합 토끼 단일클론 항체로, WB, IHC, ICC 등 다양한 응용에 적합. 높은 특이성과 민감도, 로트 간 일관성 보장. 인간, 마우스, 랫트 반응성. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | – | View 6 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | – |
| Immunocytochemistry (ICC/IF) | 3 µg/mL | – |
| Immunoprecipitation (IP) | Assay-dependent | – |
| RNA Immunoprecipitation (RIP) | Assay-dependent | – |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Avian, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 14H6L24 |
| Immunogen | Protein corresponding to Human RBFOX3 (aa 1–312) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2633050 |
Product Specific Information
This antibody is predicted to react with Monkey, Rat, and Mouse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Fox-3, also known as NeuN, HRNBP3, RBFOX3 (RNA binding protein, fox-1) or Fox-1 homolog C, is a 350 amino acid protein containing one RRM (RNA recognition motif) domain. Localized to both the nucleus and cytoplasm, Fox-3 regulates alternative splicing events.
Fox-3 is encoded by a gene located on human chromosome 17, which represents over 2.5% of the human genome and encodes more than 1,200 genes. Two key tumor suppressor genes associated with chromosome 17 are p53 and BRCA1.
- p53 maintains genetic integrity by moderating DNA repair and cell death.
- BRCA1 is involved in DNA repair and is linked to early-onset breast cancer and predisposition to cancers of the ovary, colon, prostate, and fallopian tubes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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