Thermo Fisher Scientific MARK1 Polyclonal Antibody
MARK1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 5 µg/mL 농도로 검증됨. 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. 세포극성 및 미세소관 동역학 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Bovine, Dog, Human, Non-human primate, Rabbit |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from N-terminus of human MARK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550375 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gibbon, Monkey, Marmoset, Dog, Bat, Bovine, Panda, Rabbit, Opossum (100%);
Elephant, Horse, Lizard (94%);
Rat, Turkey, Chicken, Platypus (89%).For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
MARK1 (MARK) is a serine/threonine kinase involved in cytoskeletal organization and biogenesis.
It regulates cell polarity by phosphorylating microtubule-associated proteins (MAP2, MAP4, MAPT/TAU) at KXGS motifs, leading to their detachment and disassembly.
MARK1 also regulates neuronal migration through its dual roles in cell polarity and microtubule dynamics, possibly via phosphorylation of DCX.
Additionally, it acts as a positive regulator of the Wnt signaling pathway by mediating phosphorylation of dishevelled proteins (DVL1, DVL2, DVL3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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