Thermo Fisher Scientific MARK1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MARK1 for IHC(P) applications. Recognizes multiple species with high identity. Supplied as unconjugated liquid form, purified by antigen affinity chromatography. Ideal for research on cell polarity and microtu...
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Applications
- Immunohistochemistry (Paraffin) [IHC(P)]
Tested Dilution
- 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Horse, Human, Non-human primate, Rabbit |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from N-terminus of human MARK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550376 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gibbon, Monkey, Marmoset, Horse, Rabbit (100%)
- Dog, Bovine, Panda (95%)
- Rat, Hamster, Elephant, Platypus (89%)
- Mouse, Opossum, Turkey, Chicken, Lizard (84%)
For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
MARK1 (MARK) is a serine/threonine kinase involved in cytoskeletal organization and biogenesis. It regulates cell polarity by phosphorylating microtubule-associated proteins MAP2, MAP4, and MAPT/TAU at KXGS motifs, causing their detachment from microtubules and disassembly.
MARK1 also regulates neuronal migration through dual activities in cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. It acts as a positive regulator of the Wnt signaling pathway, likely by mediating phosphorylation of dishevelled proteins (DVL1, DVL2, and/or DVL3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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