Thermo Fisher Scientific alpha Actinin 1 Polyclonal Antibody
Western blot 및 ICC/IF에 적합한 rabbit polyclonal 항체로, alpha Actinin 1 단백질을 인식합니다. 여러 종(인간, 마우스, 랫 등)에 반응하며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 4 publications |
| Immunocytochemistry (ICC/IF) | 1:25 | View 5 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Non-human primate, Rat |
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to carboxy-terminal residues of human alpha Actinin 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5 µg/mL |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10986146 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Alpha Actinin 1 belongs to the spectrin gene superfamily, a group of cytoskeletal proteins including alpha and beta spectrins and dystrophins.
Alpha actinin is an actin-binding protein with multiple roles depending on the cell type.
- In nonmuscle cells, it is found along microfilament bundles and adherens-type junctions, where it binds actin to the membrane.
- In muscle cells (skeletal, cardiac, smooth), it localizes to the Z-disc and dense bodies, anchoring myofibrillar actin filaments.
This gene encodes a nonmuscle, cytoskeletal alpha actinin isoform and maps to the same locus as the erythroid beta spectrin gene.
Three transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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